Adverse Drug Reactions Advisory Committee (ADRAC).Suitable for use in paediatrics when combined with an age-appropriate diet. These drugs include calcium channel blockers (felodipine, nifedipine), HMG–CoA reductase inhibitors (simvastatin, atorvastatin), benzodiazepines (midazolam, triazolam), cyclosporin, saquinavir and cisapride. Atorvastatin is safe to consume in addition to orange juice. Patients prescribed drugs that are metabolised by the cytochrome P450 enzymes (CYP3A4) and P-glycoprotein (Pgp) in enterocytes in the intestinal wall. However, taking atorvastatin in the evening and drinking grapefruit juice in the morning (300 mL/d from a specific lot prepared by the Florida Department of Citrus) resulted in drug serum concentrations that were 119126 of those seen with no consumption of grapefruit, with no evidence of skeletal muscle toxicity (e.g., elevated creatine. Although this may appear to be a strange interaction, certain vastatins, such asvastatin (Lipitor) and simvastatin (Zocor), can interact with grapefruit juice, increasing your risk of harmful side effects. CharacteristicsĪvoids grapefruit and any foods containing grapefruit products. Neurological side effects such as confusion and memory loss. Mild side effects include muscle and joint pain, while more severe side effects include the following: Muscle breakdown.
To provide a diet without any grapefruit or grapefruit products. Women aged 65 and older are especially likely to develop side effects from the combination.
It is not to be used for patient education. This document is part of the ACI Diet Specifications for Adult Inpatients. Eating grapefruit may negatively interact with certain statin drugs, such as atorvastatin, lovastatin, and simvastatin.
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